Teratoma
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Research from Harvard University has provided new data on germ cell cancer
2009 AUG 10 - (NewsRx.com) -- According to recent research published in the International Journal of Gynecological Pathology, "The embryonic stem cell transcription factors SOX2, NANOG, and OCT3/4 are involved in the regulation of germ cell tumor growth and differentiation. They, and D2-40 (podoplanin), an antigen expressed in seminomas, are emerging as useful diagnostic markers in testicular genii cell tumors." "This study evaluates the use of these markers in ovarian tumors. Ovarian germ cell tumors (n = 31) have distinct immunostaining profiles, depending on the type of differentiation as follows: dysgerminoma (SOX2-, NANOG+, OCT3/4+, D2-40+), embryonal carcinoma (SOX2+, NANOG+, OCT3/4+, D2-40-), immature teratomas (SOX2+, NANOG-, OCT3/4-, D2-40-), yolk sac tumors, and choriocarcinoma (SOX2-, NANOG-, OCT3/4-, D2-40-). In immature teratomas, SOX2 positivity was limited to neural and epithelial tissues, and OCT3/4 was positive only in scattered epithelial cells (<10%, of cells). Nongerm cell tumors (n = 57 including surface-epithelial stromal tumors and sex-cord stromal tumors) were negative for NANOG and D2-40. OCT3/4 was positive in 4 of 9 adult granulosa cell tumors (15% to 85% of cells). In a small number of surface-epithelial stromal tumors, SOX2 and/or OCT3/4 were variably positive (20% to 90% of cells). Of the markers, SOX2 and 132-40 discriminated between dysgerminoma and embryonal carcinoma. NANOG distinguished between either of these 2 tumors and nongerm cell tumors," wrote M.C. Chang and colleagues, Harvard University. The researchers concluded: "The inclusion of these markers should therefore be considered in cases of pure or mixed ovarian genii cell tumors that are difficult to classify, and to exclude nongerm cell tumor mimics." Chang and colleagues published their study in International Journal of Gynecological Pathology (Embryonic Stem Cell Transcription Factors and D2-40 (Podoplanin) as Diagnostic Immunohistochemical Markers in Ovarian Germ Cell Tumors. International Journal of Gynecological Pathology, 2009;28(4):347-355). For additional information, contact M.C. Chang, Harvard University, School Medical, Brigham & Women's Hospital, Dept. of Pathology, Boston, MA 02115, USA. The publisher's contact information for the International Journal of Gynecological Pathology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: United States, Boston, Chorio Cancer, Chorio Carcinoma, Diagnostics, Dysgerminoma, Embryonal Cancer, Embryonic Stem Cell Research, Germ Cell Cancer, Germ Cell Carcinoma, Gynecology, Oncology, P19 Embryonal Carcinoma, Pathology, Seminoma, Teratoma, Urology, Harvard University. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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