Studies conducted at Children's Hospital on iron overload recently published
2009 JUN 29 - (NewsRx.com) -- According to recent research from the United States, "R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days." "Forty-three patients (sickle cell anemia, n = 32; beta-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (+/- SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P<.01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P<.001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI," wrote J.S. Hankins and colleagues, Children's Hospital. The researchers concluded: "This study was registered at www.clinicaltrials.gov as #NCT00675038. (Blood. 2009;113:4853-4855)." Hankins and colleagues published their study in Blood (R2* magnetic resonance imaging of the liver in patients with iron overload. Blood, 2009;113(20):4853-4855). For additional information, contact J.S. Hankins, St. Jude Children's Hospital & Research Center, Dept. of Hematology, 262 Danny Thomas Pl, MS 800, Memphis, TN 38105, USA. Publisher contact information for the journal Blood is: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: United States, Memphis, Beta-Thalassemia, Biopsy, Blood Transfusion, Bone Marrow Failure, Gastroenterology, Hematology, Hepatology, Iron Overload, Magnetic Resonance, Medical Device, Oncology, Sickle Cell Anemia, Sickle Cell Disease, Surgery, Thalassemia, Transfusion Medicine, Children's Hospital. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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