New thrombocytopenia findings from D.J. Hilton and co-authors described
2009 JUL 20 - (NewsRx.com) -- According to a study from Parkville, Australia, "The transcription factor c-Myb and coregulator p300 have a key role in maintaining production of controlled numbers of megakaryocytes and platelets. In mice, mutations in c-Myb or p300 cause thrombocytosis in otherwise wild-type animals and can ameliorate the thrombocytopenia in mice lacking the thrombopoietin receptor, c-Mpl, a model for human congenital amegakaryocytic thrombocytopenia." "To examine whether inhibition of c-Myb/p300 is effective in other models of thrombocytopenia, the effect of the c-Myb(Plt4) mutation on thrombocytopenia associated with reduced platelet life span in Bcl-X-Plt20/Plt20 mice was assessed, as were responses in c-Myb(Plt4) and/or p300(Plt6) mutant mice to thrombocytopenia associated with antiplatelet antibodies, chemotherapy, or bone marrow transplantation. Homozygosity of the c-Myb(Plt4) allele ameliorated thrombocytopenia associated with reduced platelet life span, and c-Myb(Plt4/+) mice exhibited more rapid than normal recovery from thrombocytopenia caused by antiplatelet serum or bone marrow transplantation. Recovery to pretreatment platelet levels was unaltered in 5-fluorouracil-treated c-Myb(Plt4/+) mice relative to wild-type controls, but enhanced platelet production during subsequent thrombocytosis was evident. More modest enhancement of platelet recovery after 5-fluorouracil or bone marrow transplantation was also evident in p300(Plt6/+) animals," wrote D.J. Hilton and colleagues. The researchers concluded: "The data suggest potential utility of c-Myb/p300 as a target for therapeutic intervention in thrombocytopenia of diverse origins. (Blood. 2009; 113:5599-5604)'." Hilton and colleagues published their study in Blood (Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood, 2009;113(22):5599-5604). For more information, contact W.S. Alexander, Walter & Eliza Hall Institute Med Research, Cancer & Hematology Division, 1G Royal Parade, Parkville, Vic 3050, Australia. Publisher contact information for the journal Blood is: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: Australia, Parkville, Angiology, Bone Marrow, Chemotherapy, Drug Therapy, Hematology, Thrombocytopenia, Thrombocytosis, Thrombopoietin. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
|
