Thrombolysis
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Research conducted at University of Heidelberg has updated our knowledge about thrombolysis
2009 AUG 17 - (NewsRx.com) -- According to recent research from Mannheim, Germany, "Differences between women and men in relation to stroke are increasingly being recognized. From July 2004 until June 2007, 237 acute ischemic stroke (AIS) patients were treated with recombinant tissue plasminogen activator (rtPA) within 3 hours after onset of symptoms in our stroke unit." "Baseline characteristics, etiology, CT/MRI stroke patterns, clinical outcome, and complications of women were compared to those of men. Of 237 AIS patients (mean age 70.7 years), 111 (46.8%) were women and 126 (53.2%) were men. Women were older (P=0.001), but history of hyperlipidemia (P=0.03), smoking (P=0.03), and coronary heart disease (P <0.001) was less frequent than in men. Internal carotid artery disease occurred more often in men (P=0.02), whereas atrial fibrillation was observed more often in women (P=0.002). In men borderzone/small embolic and lacunar stroke was found more frequently (39.7 versus 27.2%), whereas women showed a higher percentage of large territorial stroke (72.8 versus 60.3%, P=0.09). Baseline National Institute of Health Stroke Scale scores (12.5 versus 11.3), NIHSS score at discharge (11.0 versus 9.5), 3-month-outcome modified Rankin Scale score, thrombolysis- related (17.1% versus 13.5%) or independent complications (32.4% versus 30.2%), and mortality after 3 months (13.5% versus 9.5%) were similar. Differences of stroke lesion patterns in genders are paralleled by differences in etiology and risk factor profiles (women, cardioembolism; men, large and small vessel disease)," wrote A. Forster and colleagues, University of Heidelberg. The researchers concluded: "Baseline characteristics, rates of rtPA-related and independent complications, as well as clinical outcomes were not different between women and men with AIS. (Stroke. 2009; 40:2428-2432.)." Forster and colleagues published their study in Stroke (Gender Differences in Acute Ischemic Stroke Etiology, Stroke Patterns and Response to Thrombolysis. Stroke, 2009;40(7):2428-2432). For additional information, contact A. Forster, University of Heidelberg, Dept. of Neurology, University of Klinikum Mannheim, D-68137 Mannheim, Germany. Publisher contact information for the journal Stroke is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Germany, Mannheim, Angiology, Atrial Fibrillation, Cardiology, Carotid Artery Disease, Coronary Heart Disease, Enzyme Research, Gender Health, Gender Medicine, Heart Disease, Hematology, Hyperlipidemia, Internal Carotid Artery, Plasminogen, Thrombolysis, Women's Health, University of Heidelberg. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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