Research from Y. Dargaud et al broadens understanding of thromboembolism
2009 JUL 20 - (NewsRx.com) -- According to recent research published in the British Journal of Haematology, "With thrombophilia and/or a history of venous thromboembolism (VTE) exhibit a high risk of thrombosis during pregnancy. The present multicentre study prospectively assessed a prophylaxis strategy, based on a risk score, in pregnancies with increased risk of VTE." "Among 286 patients included in the study, 183 had a personal history of VTE (63.98%) and 191 patients (66.8%) had a thrombophilia marker. Eighty nine (46.6%) thrombophilic women had a personal history of VTE. were assigned to one of three prophylaxis strategies according to the risk scoring system. In postpartum, all patients received low molecular weight heparin (LMWH) prophylaxis for at least 6 weeks. In antepartum, LMWH prophylaxis was prescribed to 61.8% of patients with high risk of VTE. Among them, 37.7% were treated in the third trimester only and 24.1% were treated throughout pregnancy. In this cohort, one antepartum-related VTE (0.35%) and two postpartum-related VTE (0.7%) occurred. No case of pulmonary embolism was observed during the study period. The rate of serious bleeding was 0.35%. There was no evidence of heparin-induced thrombocytopenia or osteoporosis," wrote Y. Dargaud and colleagues. The researchers concluded: "The use of a risk score may provide a rational decision process to implement safe and effective antepartum thromboprophylaxis in pregnant women at high risk of VTE." Dargaud and colleagues published their study in British Journal of Haematology (A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study. British Journal of Haematology, 2009;145(6):825-835). For additional information, contact Y. Dargaud, Hopital Edouard Herriot, Unite Hemostase Clinic, Herriot Pavillon E, 5 Pl Arsonval, F-69003 Lyon, France. The publisher's contact information for the British Journal of Haematology is: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: France, Lyon, Heparin, Obstetrics, Pregnancy, Thromboembolism, Thrombophilia, Thrombosis. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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