Researchers from University of Verona discuss findings in liver disease
2009 JUL 13 - (NewsRx.com) -- According to a study from Verona, Italy, "Nonalcoholic fatty liver disease (NAFLD), comprising its whole spectrum of conditions ranging from simple steatosis to steatohepatitis (nonalcoholic steatohepatitis; NASH) and cirrhosis, is the most frequent liver disease in developed countries and is now regarded as the liver manifestation of the metabolic syndrome." "Several studies indicate that NAFLD, especially in its necro-inflammatory form (NASH), is associated with a systemic proinflammatory/prothrombotic state, independently of shared metabolic risk factors. This Suggests that NAFLD/NASH is not simply a marker of the proinflammatory/prothrombotic state in the metabolic syndrome but is actively involved in its pathogenesis, possibly through the systemic release of proinflammatory and procoagulant factors from the steatotic liver (C-reactive protein, plasminogen activator inhibitor-1, interleukin-6, fibrinogen, and other proinflammatory cytokines)," wrote G. Targher and colleagues, University of Verona. The researchers concluded: "The clinical impact of NAFLD on the proinflammatory/prothrombotic risk profile deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD." Targher and colleagues published the results of their research in Seminars in Thrombosis and Hemostasis (Nonalcoholic Fatty Liver Disease as a Contributor to Hypercoagulation and Thrombophilia in the Metabolic Syndrome. Seminars in Thrombosis and Hemostasis, 2009;35(3):277-287). For additional information, contact G. Targher, University of Verona, Endocrinol Sect, Dept. of Biomedical & Surgery Science, Osped Civile Maggiore, Piazzale Stefani 1, I-37126 Verona, Italy. The publisher of the journal Seminars in Thrombosis and Hemostasis can be contacted at: Thieme Medical Publ Inc., 333 Seventh Avenue, New York, NY 10001, USA. Keywords: Italy, Verona, Blood Coagulation Disorder, Cirrhosis, Coagulation, Fatty Liver, Fibrosis, Hypercoagulation, Inflammation, Liver Disease, Steatosis, Thrombophilia, Thrombosis, University of Verona. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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