Study results from University of Michigan broaden understanding of adverse drug reactions
2009 AUG 3 - (NewsRx.com) -- According to a study from the United States, "The recognition that nonsteroidal anti-inflammatory drugs (NSAIDs) increase not only gastrointestinal (GI) but cardiovascular (CV) adverse events as well has created a dilemma for practicing physicians." "Clinicians selecting appropriate NSAID therapy must estimate each patient's baseline risk for both (GI) and (CV) adverse events, and then estimate the impact of each medication (and its dose) for the individual patient. To synthesize a rational current treatment approach, we have developed a 2x2 table to guide NSAID medication choice, considering the use of concomitant aspirin as well as gastroprotective therapy," wrote J.M. Scheiman and colleagues, University of Michigan. The researchers concluded: "COX-2 inhibitors were an important scientific advance in pain therapy, and using them in a safe and cost-effective manner is possible when all the competing risks are carefully weighed." Scheiman and colleagues published the results of their research in Gastroenterology Clinics of North America (Balancing Risks and Benefits of Cyclooxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology Clinics of North America, 2009;38(2):305+). For additional information, contact J.M. Scheiman, University of Michigan, School Medical, Division Gastroenterology, Dept. of Internal Medical, 3912 Taubman Center SPC 5362, Ann Arbor, MI 48109, USA. The publisher of the journal Gastroenterology Clinics of North America can be contacted at: W B Saunders Co-Elsevier Inc., 1600 John F Kennedy Boulevard, Ste. 1800, Philadelphia, PA 19103-2899, USA. Keywords: United States, Ann Arbor, Adverse Drug Reactions, Adverse Drug Effect, Adverse Drug Event, Adverse Drug Reaction, Antiinflammatory, Aspirin, Cardiology, Cardiovascular, Cyclooxygenase, Drugs, Enzymology, Gastroenterology, Gastrointestinal Bleeding, Heart Attack, Myocardial Infarction, NSAIDS, Peptic Ulcers, Pharmaceuticals, Therapy, Thrombosis, Treatment, University of Michigan. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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