Studies from University of California, Division of Rheumatology yield new information about thrombosis
2009 AUG 3 - (NewsRx.com) -- New research, 'Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis,' is the subject of a report. According to a study from the United States, "The aim of this study was to perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibody (aPL) positivity. Included studies recruited patients based on SLE or aPL-positive status, confirmed subjects' SLE diagnosis as defined by the American College of Rheumatology, and documented thrombotic events." "Excluded studies were non-English or considered only arterial thrombosis. Individual patient data, available from 5 studies, together with unpublished data from 1210 European-American SLE patients from the UCSF Lupus Genetics Collection genotyped for FVL, were further analyzed. Seventeen studies (n=2090 subjects) were included in the initial meta-analysis. Unadjusted odds ratios (OR) were calculated to assess association of FVL with thrombosis. The OR for association of thrombosis with FVL was 2.88 (95% confidence interval (CI) 1.98-4.20). In the secondary analysis with our individual patient dataset (n=1447 European-derived individuals), SLE subjects with the FVL polymorphism still had more than two times the odds of thrombosis compared to subjects without this polymorphism, even when adjusting for covariates such as gender, age and aPL status," wrote R. Kaiser and colleagues, University of California, Division of Rheumatology. The researchers concluded: "SLE and/or aPL-positive patients with the FVL variant have more than two times the odds of thrombosis compared to those without this polymorphism." Kaiser and colleagues published their study in Genes and Immunity (Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes and Immunity, 2009;10(5):495-502). For more information, contact R. Kaiser, University of California, University of California, Division of Rheumatology, San Francisco (UCSF), San Francisco, CA 94143 USA.. Publisher contact information for the journal Genes and Immunity is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: United States, San Francisco, Blood Coagulation Disorder, Rheumatology, Systemic Lupus Erythematosus, Thrombosis. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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