Studies from Emory University update current data on thromboembolism
2009 AUG 3 - (NewsRx.com) -- According to recent research published in the journal Thrombosis and Haemostasis, "Genetic determinants of venous thromboembolism (VTE) in the African-American population are poorly characterised. It was recently shown that fibrinogen gamma gene (FGG) polymorphisms 10034C >T and 9340T >C influence VTE risk in the Caucasian population." "In the African-American population these polymorphisms are common, with allele frequencies above 25%. Here we evaluated whether these and other FGG 3'-end polymorphisms were associated with VTE risk in the African-American population and aimed to replicate the association in the Caucasian population. We examined 557 Caucasian patients and 678 Caucasian controls, and 537 African-American patients and 586 African-American controls from the 'Genetic Attributes and Thrombosis Epidemiology' (GATE) study. In the African-American population, 10034C >T and 9340T >C marginally influenced VTE-risk, with a 20% increase in risk for 10034TT carriers and a 20% reduction in risk for 9340CC carriers. In the Caucasian population, 10034TT was associated with a 1.7-fold increase in risk, which increased to 2.1-fold for idiopathic VTE patients. 9340CC significantly reduced VTE risk approximately two-fold," wrote S.U. Dewillige and colleagues, Emory University. The researchers concluded: "Both FGG polymorphisms 10034C >T and 9340T >C influence VTE-risk, with the strongest effects observed in the Caucasian population, confirming previous data on these polymorphisms in this population." Dewillige and colleagues published their study in Thrombosis and Haemostasis (Fibrinogen gamma gene 3'-end polymorphisms and risk of venous thromboembolism in the African-American and Caucasian population. Thrombosis and Haemostasis, 2009;101(6):1078-1084). For additional information, contact H. Austin, Emory University, Dept. of Epidemiology, Rollins School Public Health, 1518 Clifton Rd. NE, Atlanta, GA 30322, USA. The publisher's contact information for the journal Thrombosis and Haemostasis is: Schattauer GmbH-Verlag Medizin Naturwissenschaften, Holderlinstrasse 3, D-70174 Stuttgart, Germany. Keywords: United States, Atlanta, Angiology, Haemostasis, Thromboembolism, Thrombosis, Emory University. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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