Research from University of Buenos Aires has provided new information about type 2 diabetes
2009 JUL 13 - (NewsRx.com) -- According to a study from Buenos Aires, Argentina, "We present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes. The proposed method combines both the use of open data access from two type 2 diabetes-genome-wide association." "P studies (granted by the Diabetes Genetics Initiative and the Welcome Trust Case Control Consortium) and the comprehensive analysis of candidate regions generated by the freely accessible ENDEAVOUR software. The algorithm prioritized all genes of the whole genome in relation to type 2 diabetes. There were six of 1096 single nucleotide polymorphisms in five genes potentially associated with type 2 diabetes: tachykinin receptor 3 (rs1384401), anaplastic lymphoma receptor tyrosine kinase (rs4319896), calcium channel, voltage-dependent, L type, alpha ID subunit (rs12487452), FOXO1A (rs10507486 and rs7323267), and v-akt murine thymoma viral oncogene homolog 3 (rs897959). We estimated the fixed effect and P values of each single nucleotide polymorphism in the combined dataset by Mantel-Haenszel meta-analysis and we observed significant P values for all single nucleotide polymorphisms except for rs897959 at v-akt murine thymoma viral oncogene homolog 3. The proposed strategy may be used as an alternative toot for optimizing the information of the nearly 500,000 gene variants in which markers with modest significant P value for disease association are currently disregarded," wrote S. Sookoian and colleagues, University of Buenos Aires. The researchers concluded: "Additionally, the said single nucleotide polymorphisms may be incorporated into the replication of the multistage design involved in the genome-wide association studies. Genet Med 2009:11(5):338-343." Sookoian and colleagues published their study in Genetics in Medicine (Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes. Genetics in Medicine, 2009;11(5):338-343). For more information, contact C.J. Pirola, University of Buenos Aires, Institute Med Research A Lanari, CONICET, Dept. of Molecular Genetics & Biology Complex Diseases, RA-1427 Buenos Aires, DF, Argentina. Publisher contact information for the journal Genetics in Medicine is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: Argentina, Buenos Aires, Disease Association, Enzyme Research, Genetics, Genomics, Hematology, Kinase, Lymphoma, Non-insulin Dependent Diabetes Mellitus, Oncology, Proteins, Proteomics, Type 2 Diabetes Mellitus, Tyrosine Kinase, University of Buenos Aires. This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2009, Diabetes Week via NewsRx.com.
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