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New thyroid disease prevention research reported from M.L. Browne and co-authors
2009 JUL 27 - (NewsRx.com) -- New investigation results, 'Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study,' are detailed in a study published in Birth Defects Research Part A, Clinical and Molecular Teratology. "Although thyroid disorders are present in approximately 3% of pregnant women, little is known about the association between maternal thyroid disease and birth defects. We assessed the association between maternal thyroid disease, thyroid medication use, and 38 types of birth defects among 14,067 cases and 5875 controls in the National Birth Defects Prevention Study, a multisite, population-based, case-control study," scientists in the United States report. "Infants in this study were born between October 1997 and December 2004. Information on exposures including maternal diseases and use of medications was collected by telephone interview. We found statistically significant associations between maternal thyroid disease and left ventricular outflow tract obstruction heart defects (1.5; 95% CI, 1.0-2.3), hydrocephaly (2.9; 95% CI, 1.6-5.2), hypospadias (1.6; 95% CI, 1.0-2.5), and isolated anorectal atresia (2.4; 95% CI, 1.2-4.6). Estimates for the association between periconceptional use of thyroxine and specific types of birth defects were similar to estimates for any thyroid disease. Given that antithyroid medication use was rare, we could not adequately assess risks for their use for most case groups. Our results are consistent with the positive associations between maternal thyroid disease or thyroid medication use and both hydrocephaly and hypospadias observed in some previous studies," wrote M.L. Browne and colleagues, . The researchers concluded: "New associations with left ventricular outflow tract obstruction heart defects and anorectal atresia may be chance findings." Browne and colleagues published their study in Birth Defects Research Part A, Clinical and Molecular Teratology (Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study. Birth Defects Research Part A, Clinical and Molecular Teratology, 2009;85(7):621-8). For more information, contact M.L. Browne, Congenital Malformations Registry, New York State Dept. of Health, Troy, New York USA.. Publisher contact information for the journal Birth Defects Research Part A, Clinical and Molecular Teratology is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: United States, Troy, Thyroid Disease Prevention, Cardiology, Clinical Trial Research, Pediatrics, Thyroid Disease. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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