Research from Duke University broadens understanding of thyroid disease
2009 AUG 3 - (NewsRx.com) -- "Autoimmune thyroid disease occurs in some complete DiGeorge anomaly patients after thymus transplantation. This study was designed to assess the effect of culture of thymus tissue on the expression of genes involved in the development of autoimmunity," investigators in the United States report. "The expression of autoimmune regulator (AIRE), thyroglobulin (TG), thyroid peroxidase (TPO), and cytokeratin RNAs was examined in thymocytes and thymus tissue on the day of thymus harvest and after 14 and 21 days of culture. Immunohistochemistry was used to evaluate the cytokeratin expression in the thymus tissue. AIRE, TG, TPO, and cytokeratin mRNAs were found in harvest-day, 14-day and 21-day cultured tissues," wrote B. Li and colleagues, Duke University. The researchers concluded: "Levels of AIRE, TG, and cytokeratin mRNAs were mostly higher after culture compared to expression on the harvest day, likely secondary to thymocyte depletion.." Li and colleagues published their study in Immunologic Research (Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes. Immunologic Research, 2009;44(1-3):71-83). For additional information, contact M.L. Markert, Duke University, Dept. of Immunology, Medical Center, Research Pk Bldg 4, Research Dr., Durham, NC 27710, USA. The publisher of the journal Immunologic Research can be contacted at: Humana Press Inc., 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. Keywords: United States, Durham, Autoimmune Disease, Autoimmune Disorder, Autoimmunity, Drugs, Enzyme Research, Immunology, Peroxidase, Pharmaceuticals, Therapy, Thyroglobulin, Thyroid Disease, Transplantation, Treatment, Duke University. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.
|
