Thyroid Disease

Study results from A.L.V. Barcelos et al provide new insights into dyslipidemias

Thyroid Disease Library Library Home This article was published in Diabetes Week, which you can subscribe to online.

"Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43%. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2% of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A >C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population," wrote A.L.V. Barcelos and colleagues.

The researchers concluded: "This gene represents a potential locus for a nutrigenetic directed approach."

Barcelos and colleagues published their study in Brazilian Journal of Medical and Biological Research (Association of CYP7A1-278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients. Brazilian Journal of Medical and Biological Research, 2009;42(6):487-493).

For additional information, contact C.M.D. Silva, Fundacao Estadual Prod & Pesquisa Saude, Center Desenvolvimento Cient & Tecnol, Av Ipiranga 5400, BR-90610000 Porto Alegre, RS, Brazil.

The publisher's contact information for the Brazilian Journal of Medical and Biological Research is: Association Bras Divulg Cientifica, Faculdade Medicina, Sala 21, 14049 Ribeirao Preto, Sao Paulo, Brazil.

Keywords: Brazil, Porto Alegre, Diabetes, Diabetes Mellitus, Digestion, Dyslipidemias, Endocrinology, Endonucleases, Enzyme Research, Enzymology, Gastroenterology, Genotyping, Kidney, Nephrology, Thyroid Disease.

This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2009, Diabetes Week via NewsRx.com.