New hypersensitivity research has been reported by Y. Charlijoseph et al
2009 JUL 20 - (NewsRx.com) -- "Most adverse cutaneous drug reactions (ACDR) are mediated by delayed hypersensitivity (dh) with lymphocyte recruitment and inflammatory cytokines release, including tumour necrosis factor alpha (TNF alpha). Polymorphisms in the TNF alpha gene, such as the infrequent allele TNF2, predispose to certain inflammatory entities and enhance TNF alpha production," scientists writing in the Journal of the European Academy of Dermatology and Venereology report. "The incidence of the TNF2 allele is increased in British patients with severe ACDR, suggesting TNF alpha as a major contributor in the pathogenesis of ACDR. We designed a prospective study to analyse the epidemiology of ACDR in a third-level Mexican hospital and explore the possibility of a relationship between the TNF2 allele and ACDR-dh. A prospective study during 9 months allowed recognition of 34 ACDR-dh patients. The study included 33 paired patients, and 44 healthy volunteers. All subjects were genotyped for TNF2 by PCR DNA amplification and NcoI restriction endonuclease digestion. Incidence of ACDR was 0.95%. The TNF2 allele was detected in 9.9% of the sample population with no significant differences between healthy controls, and patients with or without ACDR-dh. Only 3 of the 34 ACDR-dh subjects presented severe reactions, with 1 having the TNF2 allele. Comorbidity analysis showed significance only with autoimmune thyroid disease, consistent with reports on Chinese and Tunisian patients. ACDR incidence and TNF2/TNFA heterozygosity were lower in Mexican than in Caucasian patients," wrote Y. Charlijoseph and colleagues. The researchers concluded: "ACDR-dh patients showed no increased frequency in the TNF2 allele.None declared.." Charlijoseph and colleagues published their study in the Journal of the European Academy of Dermatology and Venereology (Incidence of adverse cutaneous drug reactions in a Mexican sample: an exploratory study on their association to tumour necrosis factor alpha TNF2 allele. Journal of the European Academy of Dermatology and Venereology, 2009;23(7):788-792). Additional information can be obtained by contacting Y. Charlijoseph, Institute Nacl Ciencias Med & Nutrition Salvador Zubiran, Mexico City, DF, Mexico. The publisher of the Journal of the European Academy of Dermatology and Venereology can be contacted at: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: Mexico, Autoimmune Disease, Autoimmune Disorder, Clinical Trial Research, Cytokines, Delayed Hypersensitivity, Dermatology, Drug Development, Epidemiology, Hypersensitivity, Immunology, Necrosis, Therapy, Thyroid Disease, Treatment, Venereology. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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