Thyroiditis

Study results from University of Pisa in the area of hepatitis C virus published

Thyroiditis Library Library Home This article was published in Hepatitis Weekly, which you can subscribe to online.

"By defining a high CXCL10 level as a value > 218 pg/mL, 2% of control 1, 14% of patients with AT, 68% of patients with hepatitis C infection, 81% of HCV+AT had high CXCL10 (P < 0.0001; chi-square). CCL2 was similar in control 1 and patients with AT. CCL2 was significantly higher in: (1) patients with hepatitis C infection than control 1 (P = 0.04; ANOVA); (2) HCV+AT than patients with AT (P = 0.03) and control 1 (P = 0.02); no difference was observed between HCV with or without AT," wrote A. Antonelli and colleagues, University of Pisa.

The researchers concluded: "Our study demonstrates: (1) higher circulating CXCL10 and CCL2 in patients with hepatitis C virus chronic infection than in controls; (2) higher CXCL10 in HCV+AT than in patients with hepatitis C infection, suggesting a stronger Th1 immune response in these patients."

Antonelli and colleagues published their study in the Journal of Interferon and Cytokine Research (CXCL10 and CCL2 Chemokine Serum Levels in Patients With Hepatitis C Associated With Autoimmune Thyroiditis. Journal of Interferon and Cytokine Research, 2009;29(6):345-351).

For additional information, contact A. Antonelli, University of Pisa, Dept. of Internal Medical, School Medical, Via Roma 67, I-56100 Pisa, Italy.

Publisher contact information for the Journal of Interferon and Cytokine Research is: Mary Ann Liebert Inc., 140 Huguenot Street, 3RD FL, New Rochelle, NY 10801, USA.

Keywords: Italy, Pisa, Autoimmune Disease, Autoimmune Disorder, Autoimmune Thyroiditis, Gastroenterology, HCV, Hepatitis C Virus, Hepatology, Immunology, Infectious Disease, Interferon, Virology, University of Pisa.

This article was prepared by Hepatitis Weekly editors from staff and other reports. Copyright 2009, Hepatitis Weekly via NewsRx.com.