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Researchers from Chang Gung Institute of Technology discuss findings in tongue cancer therapy
2009 MAY 25 - (NewsRx.com) -- New investigation results, 'Signaling pathways for induction of platelet aggregation by SAS tongue cancer cells--a mechanism of hematogenous metastasis,' are detailed in a study published in Journal of Oral Pathology & Medicine. "Tongue cancer metastasis is mainly through blood stream and possibly associated with tumor cell-induced platelet aggregation (TCIPA). Platelet aggregation was induced by different amounts of SAS tongue cancer cells with/without inhibitors and the latent period for induction of platelet aggregation was recorded," investigators in Taoyuan, Taiwan report. "Gene expression was analyzed by reverse transcriptase-polymerase chain reaction. SAS cells (4 x 10(4) to 1 x 106 cells/ml) induced platelet aggregation in a cell density-dependent manner. The latent period for induction of platelet aggregation reduced from 11.3 min (2 x 10(5) cells/ml) to 0.9 min (5 x 10(5) cells/ml). The extent of platelet aggregation increased from 39% to 76% by 2 x 10(5) and 5 x 10(5) SAS cells. Pre-treatment of SAS cells with aspirin showed little effect on its induction of platelet aggregation. SAS cells expressed tissue factor (TF) mRNA and the SAS cells-induced TCIPA was inhibited by TF neutralization antibody (5-20 microg/ml), heparin (5-10 U/ml), Hirudin fragment 54-65 (50 microg/ml) and D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone. But areca nut (AN, a betel quid component known to generate reactive oxygen species (ROS)) extract showed little effect on TF expression in SAS cells. Pre-treatment with U73122 and 2-aminoethoxydiphenylborate inhibited SAS-induced TCIPA. Interestingly, catalase suppressed SAS cells-induced TCIPA, whereas AN extract enhanced this event. These results suggest that tongue cancer cells may induce TCIPA and enhance tumor metastasis. SAS-induced TCIPA is related to TF secretion, thrombin generation and associated with Phospholipase C-Inositol triphosphate signaling and ROS production," wrote M.C. Chang and colleagues, Chang Gung Institute of Technology. The researchers concluded: "Betel quid chewing may potentially promote tongue cancer metastasis." Chang and colleagues published their study in the Journal of Oral Pathology & Medicine (Signaling pathways for induction of platelet aggregation by SAS tongue cancer cells--a mechanism of hematogenous metastasis. Journal of Oral Pathology & Medicine, 2009;38(5):434-40). For additional information, contact M.C. Chang, Biomedical Science Team, Chang Gung Institute of Technology, Taoyuan, Taiwan. The publisher of the Journal of Oral Pathology & Medicine can be contacted at: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Taiwan, Taoyuan, Tongue Cancer Therapy, Angiology, Aspirin, Diagnosis, Diagnostics, Drugs, Enzyme Research, Enzymes, Enzymology, Hematology, Oncology, Oral Pathology, Pharmaceuticals, Platelet Aggregation, Polymerase, Proteins, Proteomics, Reverse Transcriptase, Therapy, Tongue Cancer, Tongue Carcinoma, Transcriptase, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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