Researchers from University College, Institute of Neurology describe findings in movement disorder in children
2007 AUG 27 -- A report, "Antineuronal antibody status and phenotype analysis in Tourette's syndrome," is newly published data in Movement Disorders. "The Gilles de la Tourette syndrome (GTS) spectrum includes psychiatric comorbidities, mainly obsessive-compulsive disorder (OCD) and attention-deficit-hyperactivity disorder (ADHD). The role of environmental factors, e.g., antineuronal antibodies (ANeA), remains unclear," investigators in London, the United Kingdom report. "We compared the clinical features of ANeA-positive and ANeA-negative patients in 53 children and 75 adults with GTS. All diagnoses were made according to DSM-IV-TR criteria. A positive ANeA Western immunoblot showed bands for at least 1 of 3 reported striatal antigens (40, 45, and 60 kDa). Twelve children (23%) and 18 adults (25%) with GTS were ANeA-positive. Disease duration, tic phenomenology and severity, frequency of echo/pali/coprophenomena, self-injurious and aggressive behavior, or frequency of OCD comorbidity did not significantly differ between ANeA-positive and negative patients. Similar findings were obtained analyzing separately the three different antibody reactivities. A comorbid diagnosis of ADHD was significantly less frequent in GTS patients positive for the anti-60 kDa antibody only. Using a multivariate logistic regression model, adjusting for age, gender, and age at disease onset, a comorbid diagnosis of ADHD remained inversely associated with anti-60 kDa antibodies (odds ratio=0.14; p=0.002; 95% confidence interval 0.04-0.49)," wrote D. Martino and colleagues, University College, Institute of Neurology. The researchers concluded: "ANeA status does not differentiate a specific phenotype of GTS." Martino and colleagues published their study in Movement Disorders (Antineuronal antibody status and phenotype analysis in Tourette's syndrome. Movement Disorders, 2007;22(10):1424-9). For additional information, contact D. Martino, Institute of Neurology, Dept. of Neuroinflammation, University College London, London, UK. The publisher of the journal Movement Disorders can be contacted at: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: United Kingdom, London, Movement Disorders, Central Nervous System Disease, Movement Disorder, Tourette Syndrome. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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