Research on Bacillus calmette-guerin vaccines published by scientists at Max Planck Institute for Infection Biology, Department of Immunology
2007 AUG 27 -- A report, "Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis," is newly published data in Proceedings of the National Academy of Sciences of the United States of America. According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live bacterial vaccine. However, limited information is available correlating route and dose of vaccination and induction of specific T cell responses with protection against tuberculosis." "We compared efficacy of oral and systemic vaccination and correlated vaccine-induced T cell responses with protection in experimental tuberculosis of mice. After oral and systemic vaccination, we observed profound differences in persistence and dissemination of BCG and frequencies and location of specific IFN-gamma-secreting CD4(+) and CD8(+) T cells. Yet, both vaccination routes caused comparable levels of protection against aerosol challenge with Mycobacterium tuberculosis. Protection correlated best with rapid accumulation of specific CD8(+) T cells in infected tissues of challenged mice. In contrast, specific IFN-gamma production by CD4(+) T cells reflected the load of M. tuberculosis rather than the strength of protection," wrote H.W. Mittrücker and colleagues, Max Planck Institute for Infection Biology, Department of Immunology. The researchers concluded: "Our data question the measurement of IFN-gamma secretion by CD4(+) T cells and emphasize the need for new biomarkers for evaluation of tuberculosis vaccine efficacies." Mittrücker and colleagues published their study in Proceedings of the National Academy of Sciences of the United States of America (Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 2007;104(30):12434-9). For additional information, contact H.W. Mittrücker, Max Planck Institute for Infection Biology, Dept. of Immunology, Cariteplatz 1, 10117 Berlin, Germany. The publisher's contact information for the journal Proceedings of the National Academy of Sciences of the United States of America is: National Acad Sciences, 2101 Constitution Avenue NW, Washington, DC 20418, USA. Keywords: Germany, Berlin, BCG Vaccines, Bacillus Calmette-Guerin Vaccines, Biotechnology, Immunization, Mycobacteria, Mycobacterium Tuberculosis, Vaccination. This article was prepared by Pharma Business Week editors from staff and other reports. Copyright 2007, Pharma Business Week via NewsRx.com.
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