Reports outline cell biology research from University of Notre Dame, Center for Global Health
2007 NOV 20 -- Research findings, 'Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo,' are discussed in a new report. According to a study from the United States, "Intracellular pathogens and the molecules they express have limited contact with the immune system. Here, we show that macrophages infected with intracellular pathogens Mycobacterium tuberculosis, M bovis BCG, Salmonella typhimurium, or Toxoplasma gondii release from cells small vesicles known as exosomes which contain pathogen-associated molecular patterns (PAMPs)." "These exosomes, when exposed to uninfected macrophages, stimulate a proinflammatory response in a Toll-like receptor-and myeloid differentiation factor 88-dependent manner. Further, exosomes isolated from the bronchoalveolar lavage fluid (BALF) of M bovis BCG-infected mice contain the mycobacteria components lipoarabinomannan and the 19-kDa lipoprotein and can stimulate TNF-alpha production in naive macrophages. Moreover, exosomes isolated from M bovis BCG-and M tuberculosis-infected macrophages, when injected intranasally into mice, stimulate TNF-alpha and IL-12 production as well as neutrophil and macrophage recruitment in the lung," wrote S. Bhatnagar and colleagues, University of Notre Dame, Center for Global Health. The researchers concluded: "These studies identify a previously unknown function for exosomes in promoting intercellular communication during an immune response to intracellular pathogens, and we hypothesize that extracellular release of exosomes containing PAMPs is an important mechanism of immune surveillance." Bhatnagar and colleagues published the results of their research in Blood (Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood, 2007;110(9):3234-44). For additional information, contact S. Bhatnagar, University of Notre Dame, Dept. of Biological Sciences, Center for Global Health and Infectious Diseases, 130 Galvin Life Science Center, Notre Dame, IN 46556 USA.. The publisher of the journal Blood can be contacted at: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: United States, Notre Dame, Cell Biology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
|
