Tumor Suppression

Scientists at Peking Union Medical College discuss research in cardia cancer risk factors

Tumor Suppression Library Library Home This article was published in Clinical Oncology Week, which you can subscribe to online.

"This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 promoter (T309G) and their associations with risk of developing gastric cardia adenocarcinoma (GCA) in a Chinese population. Luciferase assays consistently showed a significantly higher activity of the MDM2 309G promoter compared with the MDM2 309T promoter. In cells co-transfected with variant P53 cDNAs, P53-72Pro displayed a significantly higher ability to activate the MDM2 promoter than P53-72Arg. Genotype analyses in 500 GCA patients and 1000 controls showed that significantly increased risk for developing GCA was associated with the MDM2 309G and the P53 72Pro allele compared with the MDM2 309T and the P53 72Arg allele in an allele dose-dependent manner. A joint effect between the MDM2 and P53 polymorphisms in intensifying GCA risk was detected, with the odds ratio (OR) for the presence of both MDM2 390GG and P53 72Pro/Pro genotypes being 5.05 [95% confidence interval (CI), 2.50-10.20]," wrote M. Yang and colleagues, Peking Union Medical College.

The researchers concluded: "These results suggest that the P53 72Pro and MDM2 309G polymorphisms contribute to the risk of developing GCA."

Yang and colleagues published their study in Carcinogenesis (Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. Carcinogenesis, 2007;28(9):1996-2001).

For additional information, contact M. Yang, Cancer Institute, Dept. of Etiology and Carcinogenesis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Publisher contact information for the journal Carcinogenesis is: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England.

Keywords: People's Republic of China, Beijing, Cardia Cancer Risk Factors, Carcinogenesis, Cardia Cancer, Cardia Carcinoma, Oncology, Tumor Suppression.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.