Research results from Wistar Institute update knowledge of life sciences
2007 NOV 20 -- A new study, 'The many faces of Notch signaling in skin-derived cells,' is now available. According to recent research from the United States, "Since the cloning of the Drosophila gene in the 1980s, decades of research have sought to dissect the intricacies of the mammalian Notch signaling cascade. The intrigue of this pathway undoubtedly lies in its ability to influence diverse cellular processes, including differentiation, cell fate, homeostasis, survival, proliferation and angiogenesis." "Based on its evolutionary conservation and its fundamental role in development, it is not surprising that deregulation of the Notch signaling pathway can result in neoplastic growth. While originally of particular interest to immunologists based on its chief role in influencing T-cell fate decisions and tumor oncogenesis in T-cell acute lymphoblastic leukemia, pigment cell biologists have recently taken notice of the Notch cascade based on studies suggesting the importance of this pathway in regulating melanocyte stem cell survival and melanoma progression," wrote C.C. Pinnix and colleagues, Wistar Institute. The researchers concluded: "We will review the Notch signaling literature as it relates to skin homeostasis, melanocytic stem cells and melanoma tumorigenesis." Pinnix and colleagues published their study in Pigment Cell Research (The many faces of Notch signaling in skin-derived cells. Pigment Cell Research, 2007;20(6):458-65). For additional information, contact C.C. Pinnix, The Wistar Institute, Philadelphia, PA USA.. Publisher contact information for the journal Pigment Cell Research is: Blackwell Munksgaard, 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark. Keywords: United States, Philadelphia, Life Sciences. This article was prepared by Science Letter editors from staff and other reports. Copyright 2007, Science Letter via NewsRx.com.
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