Study data from Vanderbilt University, Vanderbilt-Ingram Comprehensive Cancer Center update understanding of cancer
2007 NOV 19 -- Data detailed in 'Modulation of NFkappaB activity and e-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility' have been presented. According to a study from the United States, "Transforming growth factor beta is growth-inhibitory in non-transformed epithelial cells but becomes growth-promoting during tumorigenesis. The role of the type I and II receptors in tumorigenesis has been extensively studied, but the role of the ubiquitously expressed type III receptor (TbetaRIII) remains elusive." "We developed short hairpin RNAs directed against TbetaRIII to investigate the role of this receptor in breast cancer tumorigenesis. Nontumorigenic NMuMG mouse cells stably expressing short hairpin RNA specific to mouse TbetaRIII (NM-kd) demonstrated increased cell growth, motility, and invasion as compared with control cells expressing shRNA to human TbetaRIII (NM-con). Reconstitution of TbetaRIII expression with rat TbetaRIII abrogated the increased growth and motility seen in the NM-kd cells. In addition, the NM-kd cells exhibited marked reduction in the expression of the adherens junction protein, E-cadherin. This loss of E-cadherin was due to increased NFkappaB activity that, in turn, resulted in increased expression of the transcriptional repressors of E-cadherin such as Snail, Slug, Twist, and Sip1. Finally, NMuMG cells in which TbetaRIII had been knocked down formed invasive tumors in athymic nude mice, whereas the control cells did not," wrote T.L. Criswell and colleagues, Vanderbilt University, Vanderbilt-Ingram Comprehensive Cancer Center. The researchers concluded: "These data indicate that TbetaRIII acts as a tumor suppressor in nontumorigenic mammary epithelial cells at least in part by inhibiting NFkappaB-mediated repression of E-cadherin." Criswell and colleagues published their study in the Journal of Biological Chemistry (Modulation of NFkappaB activity and e-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility. Journal of Biological Chemistry, 2007;282(44):32491-500). For more information, contact T.L. Criswell, Vanderbilt-Ingram Comprehensive Cancer Center, Dept. of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6307 USA.. Publisher contact information for the Journal of Biological Chemistry is: American Society Biochemistry Molecular Biology Inc., 9650 Rockville Pike, Bethesda, MD 20814-3996, USA. Keywords: United States, Nashville, Biological Chemistry, Cancer, Oncology. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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