Studies from M. Hager and co-researchers yield new data on gene therapy
2007 NOV 19 -- A report, 'PTEN expression in renal cell carcinoma and oncocytoma and prognosis,' is newly published data in Pathology. According to recent research published in the journal Pathology, "Deletion or inactivation of the tumor suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression." "Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis," wrote M. Hager and colleagues, . The researchers concluded: "However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival." Hager and colleagues published their study in Pathology (PTEN expression in renal cell carcinoma and oncocytoma and prognosis. Pathology, 2007;39(5):482-5). For additional information, contact M. Hager, Paracelsus Medical University, Dept. of Pathology, Mullner Hauptstrasse 48, A-5020 Salzburg, Austria. The publisher's contact information for the journal Pathology is: Carfax Publishing, Rankine Rd., Basingstoke RG24 8PR, Hants, England. Keywords: Austria, Salzburg, Biotechnology, Cancer, Carcinoma, Gene Therapy, Genetics, Genomics, Kidney, Nephrology, Oncocytoma, Oncology, Pathology, Renal Cell Cancer, Renal Cell Carcinoma, Tumor Suppression. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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