Scientists at Memorial Sloan Kettering Cancer Center target gene therapy
2007 NOV 19 -- Current study results from the report, 'Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling,' have been published. According to recent research from the United States, "Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair." "Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation," wrote G.G. Wang and colleagues, Memorial Sloan Kettering Cancer Center. The researchers concluded: "In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer." Wang and colleagues published their study in Trends In Molecular Medicine (Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends In Molecular Medicine, 2007;13(9):373-80). For additional information, contact G.G. Wang, Laboratory of Chromatin Biology, The Rockefeller University and Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York City, NY 10021 USA.. Publisher contact information for the journal Trends In Molecular Medicine is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: United States, New York, Biotechnology, Cancer, Gene Therapy, Molecular Medicine, Oncology. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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