Turner Syndrome

Reports from University Nacional of Cordoba highlight recent research in syndrome therapy

Turner Syndrome Library Library Home This article was published in Biotech Business Week, which you can subscribe to online.

"We have previously reported that supraphysiological IGF-I levels diminished TH actions in rat tissues by reducing the nuclear TH receptor (TR). GH treatment to TS patients induces high IGF-I levels and therefore a reduction of TH action in tissues may be expected. We aimed at evaluating the effect of GH therapy in TS girls on peripheral TH action. AND We set up a reverse transcription-polymerase chain reaction (RT-PCR) for TR mRNA estimation in peripheral blood mononuclear cells (PBMC) and compared TR mRNA levels from 10 normal, 10 TS and 10 TS girls under GH therapy (0.33 mg/kg/week for 0.5-2 years). After RNA extraction from PBMC, TR and beta-actin mRNAs were coamplified by RT-PCR. In addition serum biochemical markers of TH action were measured: thyrotropin (TSH), sex hormone binding globulin (SHBG), osteocalcin (OC), beta-crosslaps (beta-CL), iodothyronines by electrochemiluminescency and IGF-I by immunoradiometric assay (IRMA) with extraction. TR mRNAs from PBMC were reduced in TS patients under GH treatment. In turn, serum TSH, OC, beta-CL and IGF-I were increased while SHBG was reduced by GH treatment in TS patients. GH treatment reduced TR expression in PBMC and biochemical serum markers of TH action," wrote S. Susperreguy and colleagues, University Nacional of Cordoba.

The researchers concluded: "These results suggest that GH treatment in TS patients impair peripheral TH action at tissue level and prompt a role in the reduced growth response to the therapy."

Susperreguy and colleagues published their study in Clinical Endocrinology (Growth hormone (GH) treatment reduces peripheral thyroid hormone action in girls with Turner syndrome. Clinical Endocrinology, 2007;67(4):629-36).

For additional information, contact S. Susperreguy, Universidad Nacional de Cordoba, Facultad de Ciencias Quimicas, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Argentina.

Publisher contact information for the journal Clinical Endocrinology is: Blackwell Publishing Ltd., 9600 Garsington Rd., Oxford OX4 2DG, Oxon, England.

Keywords: Argentina, Syndrome Therapy, Clinical Endocrinology, Hormones, IGF I, Syndrome, Therapy, Treatment.

This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.