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Recent findings from University of Virginia highlight research in liver disease
2009 JUN 15 - (NewsRx.com) -- "Plasma-based products are commonly used in patients who have chronic liver disease to treat perceived coagulopathy despite unproven efficacy and potentially severe risks, such as transfusion-related acute lung injury, which carries a high mortality rate. Moreover, volume expansion may acutely worsen portal hypertension and increase bleeding from the collateral portal vascular bed," researchers in the United States report. "Although factor replacement therapy may be warranted in selected situations, its use should be restricted because of the limitations of target tests, such as international normalized ratio, which poorly reflects presence of bleeding diatheses in patients who have cirrhosis. Renal replacement therapies are frequent adjuncts in patients who have cirrhosis and are acutely decompensated, and may correct uremia-related bleeding diathesis and assist in controlling vascular volume, although they are generally limited to use as a bridge to liver transplantation. Novel extracorporeal therapies are emerging and may also have significant interaction with the hemostatic system," wrote C.K. Argo and colleagues, University of Virginia. The researchers concluded: "Volume contraction and blood conservation therapies are relatively new and promising approaches to reduce use of blood products in liver transplantation." Argo and colleagues published their study in Clinics in Liver Disease (Blood Products, Volume Control, and Renal Support in the Coagulopathy of Liver Disease. Clinics in Liver Disease, 2009;13(1):73+). For additional information, contact C.K. Argo, University of Virginia, Dept. of Medical, Division Gastroenterology & Hepatology, Box 800708, Charlottesville, VA 22903, USA. Publisher contact information for the journal Clinics in Liver Disease is: W B Saunders Co-Elsevier Inc., 1600 John F Kennedy Boulevard, Ste. 1800, Philadelphia, PA 19103-2899, USA. Keywords: United States, Box, Blood Products, Blood Transfusion, Chronic Liver Disease, Hepatology, Infectious Disease, Kidney, Medical Device, Nephrology, Portal Hypertension, Pulmonology, Respiratory Infection, Therapy, Transfusion Medicine, Treatment, University of Virginia. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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