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Studies from Hamburg University of Technology in the Area of Molecular Microbiology Published

2013 JAN 8 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Molecular Microbiology. According to news reporting originating in Hamburg, Germany, by NewsRx journalists, research stated, "Human FOXP3(+)CD25(+)CD4(+) regulatory Tcells (Tregs) are essential to the maintenance of immune homeostasis. Several genes are known to be important for murine Tregs, but for human Tregs the genes and underlying molecular networks controlling the suppressor function still largely remain unclear."

The news reporters obtained a quote from the research from the Hamburg University of Technology, "Here, we describe a strategy to identify the key genes directly from an undirected correlation network which we reconstruct from a very high time-resolution (HTR) transcriptome during the activation of human Tregs/CD4(+) T-effector cells. We show that a predicted top-ranked new key gene PLAU (the plasminogen activator urokinase) is important for the suppressor function of both human and murine Tregs. Further analysis unveils that PLAU is particularly important for memory Tregs and that PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways. Our study demonstrates the potential for identifying novel key genes for complex dynamic biological processes using a network strategy based on HTR data, and reveals a critical role for PLAU in Treg suppressor function."

According to the news reporters, the research concluded: "Molecular Systems Biology 8:624; published online 20 November 2012; doi:10.1038/msb.2012.56."

For more information on this research see: PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells. Molecular Systems Biology, 2012;8():42-60. Molecular Systems Biology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Molecular Systems Biology - www.nature.com/msb/)

Our news correspondents report that additional information may be obtained by contacting F. He, Hamburg Univ Technol, Inst Bioproc & Biosyst Engn, Hamburg, Germany.

Keywords for this news article include: Europe, Hamburg, Germany, Molecular Microbiology

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