Waldenstrom Macroglobulinemia
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Study results from M.L. Mcmaster and colleagues broaden understanding of monoclonal gammopathy of undetermined significance
2009 MAY 18 - (NewsRx.com) -- According to a study from the United States, "Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown." "Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected," wrote M.L. Mcmaster and colleagues. The researchers concluded: "Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway." Mcmaster and colleagues published their study in Clinical Lymphoma & Myeloma (Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia. Clinical Lymphoma & Myeloma, 2009;9(1 Sp. Iss.):19-22). For more information, contact M.L. Mcmaster, 6120 Execut Blvd., Rm 7010, Bethesda, MD 20892, USA. Publisher contact information for the journal Clinical Lymphoma & Myeloma is: Cig Media Group, Lp, 3500 Maple Avenue, Ste. 750, Dallas, TX 75219-3931, USA. Keywords: United States, Bethesda, Genetics, Hematology, Hypergammaglobulinemia, Lymphoma, Monoclonal Gammopathy of Undetermined Significance, Myeloma, Oncology, Paraproteinemias, Waldenstrom Macroglobulinemia. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
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