Wegener Granulomatosis
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New mononucleosis findings from S. Varani and co-authors described
2009 JUN 29 - (NewsRx.com) -- According to recent research from Stockholm, Sweden, "Human cytomegalovirius (HCMV) is frequently detected in autoimmune diseases, but its role in such disorders is poorly understood. Herein we describe the case of a young woman who developed generalized Wegener's granulomatosis (WG) after HCMV mononucleosis and urinary tract infection." "During mononucleosis, the patient had extraordinarily high plasma levels of proinflammatory cytokines such as interleukin-5 and lymphotoxin alpha, autoantibodies, and a higher blood level of viral DNA than were found in other immunocompetent patients infected with HCMV or healthy controls. Active HCMV replication was detected after the onset of vasculitis, and HCMV genomes or antigens were found in blood, urine, and inflammatory lesions on the kidney," wrote S. Varani and colleagues. The researchers concluded: "Thus, HCMV may have triggered or exacerbated inflammation and autoimmunity in this case of WG." Varani and colleagues published their study in Arthritis and Rheumatism (Generalized Wegener's Granulomatosis in an Immunocompetent Adult After Cytomegalovirus Mononucleosis and Bacterial Urinary Tract Infection. Arthritis and Rheumatism, 2009;60(5):1558-1562). For additional information, contact S. Varani, Karolinska Institute, Center Molecular Medical, Dept. of Medical, S-17176 Stockholm, Sweden. Publisher contact information for the journal Arthritis and Rheumatism is: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: Sweden, Stockholm, Arthritis, Autoimmune Diseases, Autoimmune Disorder, Cytokines, Cytomegalovirus, Dermatology, Granulomatosis, Immunology, Infectious Disease, Mononucleosis, Rheumatism, Rheumatology, Urinary Tract Infection, Urology, Wegener Granulomatosis. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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