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Research results from S. Katsuno and colleagues update understanding of gastroenterology
2009 JUN 15 - (NewsRx.com) -- "We hypothesized neuronal disorders of the biliary tract as the cause of congenital biliary dilation (CBD). Gallbladders were removed from a total of 15 patients who were categorized into two study groups: a CBD group (eight patients) and in a control group (neuroblastoma, acute myelogenous leukemia, wandering gallbladder, Wilms' tumor, glycogen storage disease, familial amyloid polyneuropathy; seven patients)," investigators in Karimata, Japan report. "Whole-mount preparations of the gallbladders were made to immunostain the intramural nerves. The intramural vascularity in the gallbladders of the CBD group (5.5 +/- A 1.9/cm(2)) was significantly lower than that in the control group (27.6 +/- A 14.4/cm(2)). The rate of perivascular plexuses on the surface of intramural vessels was also significantly lower in the CBD group than in the controls (37.7 +/- A 18.1 vs. 80.2 +/- A 17.4%, respectively). The numbers of ganglion cells per visual field were 38.5 +/- A 24.0 and 42.3 +/- A 20.6, respectively, in the CBD and control groups; this difference was not statistically significant," wrote S. Katsuno and colleagues. The researchers concluded: "There may be a mechanism in CBD causing contractile failure and dilatation of the biliary tract as a result of decreased intramural blood flow that accompanies the diminished vascularity." Katsuno and colleagues published their study in the Journal of Hepato - Biliary - Pancreatic Surgery (Hypogenesis of intramural vascularity and perivascular plexuses of gallbladder in patients with congenital biliary dilatation. Journal of Hepato - Biliary - Pancreatic Surgery, 2009;16(3):339-345). For additional information, contact S. Katsuno, Aichi Med University, School Medical, Dept. of Surgery Gastroenterology, 21 Karimata, Aichi 4801195, Japan. The publisher of the Journal of Hepato - Biliary - Pancreatic Surgery can be contacted at: Springer Tokyo, 1-11-11 Kudan-Kita, Chiyoda-Ku, Tokyo, 102-0073, Japan. Keywords: Japan, Karimata, Acute Myelogenous Leukemia, Amyloid Polyneuropathy, Gallbladder, Gastroenterology, Glycogen Storage Disease, Hematology, Hepato-Biliary-Pancreatic Surgery, Neuroblastoma, Oncology, Pancreas, Polyneuropathies, Wilms Tumor, Wilms' Tumor. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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