HIV/AIDS Vaccine

Systemic priming with mucosal boosting shows promise in animals

Published in AIDS Vaccine Week, June 30th, 2003

by Michael Greer, senior medical writer - Vaccine researchers in the United States say that a mixture of systemic and mucosal immunization may offer improved protection against HIV infection.

"Although most HIV-1 infections worldwide result from heterosexual transmission, most vaccine candidates have focused on induction of systemic immunity and protection," explained Zandrea Ambrose and colleagues at the University of Washington in Seattle, Tulane University in New Orleans, Duke University in Durham, North Carolina, and Therion Biologics in Cambridge, Massachusetts.

A vaccine regimen combining systemic priming and mucosal boosting produced effective...

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Source: AIDS Vaccine Week (2003-06-30)

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