AIDS/HIV Vaccine

Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity

Published in AIDS Vaccine Week, November 29th, 2004

Oral immunization with papillomavirus pseudoviruses encoding gag induced HIV-1 gag-specific mucosal immunity.

"Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV) transmission. Because systemic immunization, in general, does not induce effective mucosal immune responses, a mucosal HIV vaccine is urgently needed. For this study, we developed papillomavirus pseudoviruses that express HIV-1 Gag. The pseudoviruses are synthetic, nonreplicating viruses, yet they can produce antigens for a long time in the immune system," investigators in the United States report.

"Here we show that oral immunization of mice by the use of...

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Source: AIDS Vaccine Week (2004-11-29)

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