HIV/AIDS Infection

Model of oral HIV exposure reveals extensive tonsil binding of HIV

Published in AIDS Vaccine Week, January 17th, 2005

A model system of oral HIV exposure, using human palatine tonsil, reveals extensive binding of HIV infectivity, with limited progression to primary infection.

According to a study from the United States, "Oral exposure to human immunodeficiency virus (HIV) type 1 results in systemic infection, but many details surrounding virus transmission remain unresolved. We developed a mucosal model, using human palatine tonsil with intact external epithelium, to study events after oral exposure to HIV. When applied to the external epithelium, semen from an HIV-seropositive patient and cell-free virus both established HIV infection in individual tonsillar cells. However, clusters...

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Source: AIDS Vaccine Week (2005-01-17)

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