HIV/AIDS Vaccines

Safety of HeLa-based cell substrates in HIV vaccine reported

Published in AIDS Vaccine Week, May 30th, 2005

Researchers report the safety of HeLa-based cell substrates used in the manufacture of a recombinant adeno-associated virus-HIV vaccine in a recent issue of the journal Vaccine.

"The use of transformed cell substrates for prophylactic vaccine manufacturing is widely debated. Extensive characterization is required to address the suitability of neoplastic cell substrates for vaccine manufacture. The HeLa-based cell substrate used in the manufacture of a prophylactic rAAV-HIV vaccine, AAV2-gagPR Delta RT (tgAAC09) was tested in vivo for its tumor-forming potential, the oncogenic potential of its high molecular weight DNA and the potential presence of occult...

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Source: AIDS Vaccine Week (2005-05-30)

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