HIV/AIDS Vaccine
Quaternary neutralizing epitope on HIV-1 virus particles may be vaccine target
Published in AIDS Vaccine Week, July 11th, 2005
"The selection of human monoclonal antibodies (MAbs) specific for human immunodeficiency virus (HIV) type I by binding assays may fail to identify Abs to quaternary epitopes on the intact virions," investigators in the United States report.
"The HIV neutralization assay was used for the selection of human MAb 2909, which potently neutralizes SF162 and recognizes an epitope on the virus surface but not on soluble proteins.
"Three regions of gp120, the V2 and V3 loops and the CD4 binding domain, contribute to the epitope...
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Source: AIDS Vaccine Week (2005-07-11)
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