HIV/AIDS Drug Resistance
Some HIV-1 R5 V3 loop structures acquire resistance to CCR5 binding inhibitors
Published in AIDS Vaccine Week, October 31st, 2005
"The human immunodeficiency virus (HIV-1) envelope glycoprotein (GP) 120 interacts with CD4 and the CCR5 coreceptor for viral entry. The V3 loop in GP120 is a crucial region for determining coreceptor usage during viral entry, and a variety of amino acid substitutions has been observed in clinical isolates," scientists in Japan report.
"To construct an HIV-1 V3 loop library, we chose 10 amino acid positions in the V3 loop and incorporated random combinations (27,648 possibilities) of the amino acid substitutions derived from 31 R5 viruses into the V3 loop of...
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Source: AIDS Vaccine Week (2005-10-31)
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