HIV/AIDS Vaccine
Adenoviruses encoding HIV Tat and SIV Gag enhanced cellular immunity to SIV Gag
Published in AIDS Vaccine Week, January 9th, 2006
According to researchers in the United States, "Among candidate antigens for human immunodeficiency virus (HIV) prophylactic vaccines, the regulatory protein Tat is a critical early target, but has a potential for immune suppression.":
"Adenovirus (Ad) recombinants encoding wild-type HIV Tat (Tat-wt) and a transdominant negative mutant HIV Tat (Tat22) were constructed and administered to mice separately or together with Ad-SIVgag. Immumogenicity and effects on immune responses to the co-administered Gag immunogen were evaluated....
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Source: AIDS Vaccine Week (2006-01-09)
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