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HIV/AIDS Vaccine

Boost regimen induced HIV type 1-specific T cells

Published in AIDS Vaccine Week, January 9th, 2006

A modified virus Ankara boost regimen induced human immunodeficiency virus type 1-specific T cells.

According to recent research from England, "In the absence of strategies for reliable induction of antibodies broadly neutralizing human immunodeficiency virus type 1 (HIV-1), vaccine efforts have shifted toward the induction of cell-mediated immunity. We describe the construction and immunogenicity of novel T-cell vaccine NS1.HIVA, which delivers the HIV-1 clade A consensus-derived immunogen HIVA on the surface of tubular structures spontaneously formed by protein NS1 of bluetongue virus."

"We demonstrated that NS1 tubules can accommodate a protein as...

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