Pathogenesis

CTL Important in Acute HIV Syndrome

Published in AIDS Weekly Plus, August 7th, 1995

Cytotoxic T lymphocytes with markers of immunologic activation or memory could play an important role in the earliest phases of acute HIV syndrome.

HIV infection is often accompanied by an acute viral syndrome with manifestations that may include fever, malaise, lymphadenopathy, pharyngitis, rash, myalgia, arthralgia, anorexia, headache, and nausea. This illness may last for a few days to a few weeks, and then no clinical signs may be present for years.

While the immunological changes seen during the later phases of HIV infection are well characterized, those seen during the earliest phases of acute infection are not well known. Case reports have...

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Source: AIDS Weekly Plus (1995-08-07)

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