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Pasteur Institute, Lille

Genes involved in murabutide-induced HIV suppression identified

Published in AIDS Weekly and Law, March 18th, 2004

Genes involved in murabutide-induced HIV suppression have been identified.

"The synthetic immunomodulator murabutide has been found to suppress human immunodeficiency virus type-1 (HIV-1) replication, in macrophages, through a regulated expression of cellular factors needed at different steps in the virus replication cycle," virologists in France explained.

"To identify cellular genes implicated in the murabutide-induced virus inhibition," M.J. Truong and colleagues working at the Pasteur Institute in Lille "carried out a differential display analysis on HIV-1-infected macrophages that were treated, or not, with murabutide."

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