National Jewish Medical Center, Denver
d4T treatment enhances mitochondrial oxidative stress
Published in AIDS Weekly and Law, October 28th, 2004
"The toxicity of nucleoside reverse transcriptase inhibitors (NRTIs) is linked to altered mitochondrial DNA (mtDNA) replication and subsequent disruption of cellular energetics. This manifests clinically as elevated concentrations of lactate in plasma. The mechanism(s) underlying how the changes in mtDNA replication lead to lactic acidosis remains unclear," researchers in the United States report.
"It is hypothesized that mitochondrial oxidative stress links the changes in mtDNA replication to mitochondrial dysfunction and ensuing NRTIs toxicity. To test this hypothesis," wrote L.W. Velsor and...
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Source: AIDS Weekly and Law (2004-10-28)
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