Published in AIDS Weekly and Law, January 19th, 2006
Study 1: CXCR4 TM residue mutations selectively decrease HIV-1-mediated cell fusion but not the binding activity of SDF-1alpha.
According to recently published research from the United States, "The entry of human immunodeficiency virus type 1 (HIV-1) into the cell is initiated by the interaction of the viral surface envelope protein with two cell surface components of the target cell, CD4 and a chemokine coreceptor, usually CXCR4 or CCR5. The natural ligand of CXCR4 is stromal cell-derived factor 1 alpha (SDF-1 alpha).
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