Waseda University, Tokyo
DNA double-strand breaks induced by HIV-1 Vpr
Published in AIDS Weekly and Law, March 30th, 2006
According to recent research from Japan, "Recent observations imply that HIV-1 infection induces chromosomal DNA damage responses. However, the precise molecular mechanism and biological relevance are not fully understood."
"Here, we report that HIV-1 infection causes double-strand breaks in chromosomal DNA. We further found that Vpr, an accessory gene product of HIV-1, is a major factor responsible for HIV-1-induced double-strand breaks," wrote H. Tachiwana and colleagues at Waseda University in Tokyo.
"The purified Vpr protein promotes double-strand breaks when incubated with isolated...
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Source: AIDS Weekly and Law (2006-03-30)
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