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U.S. Food & Drug Administration

Baseline protease genotype affects HIV response to atazanavir/ritonavir

Published in AIDS Weekly and Law, June 8th, 2006

Baseline protease genotype affects the HIV response to atazanavir/ritonavir in treatment-experienced patients.

Researchers in the United States conducted a study "to assess the virologic response rates of atazanavir/ritonavir and lopinavir/ritonavir based on baseline genotype and phenotype."

"Resistance analyses were performed on a Bristol-Myers Squibb-sponsored study comparing the safety and efficacy of atazanavir/ritonavir to lopinavir/ritonavir in treatment-experienced subjects at 48 weeks," explained Lisa K. Naeger and Kimberly A. Struble at the U.S. Food and Drug Administration. "Analyses evaluated virologic response based on the presence of...

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