Temple University, U.S.
HIV Tat positively affects polyomavirus BK early promoter transcription by dual mechanism
Published in AIDS Weekly and Law, August 17th, 2006
According to recent research published in the Journal of General Virology, "Polyomavirus BK (BKV) is a serious problem for immunocompromised patients, where latent virus can enter into the lytic cycle causing cytolytic destruction of host cells. BKV infects >80% of the population worldwide during childhood and then remains in a latent state in the kidney."
"In the context of immunosuppression in kidney transplant patients, reactivation of the viral early promoter (BKVE) results in production of T antigen, enabling virus replication and transition...
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Source: AIDS Weekly and Law (2006-08-17)
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