HIV/AIDS Therapy
Studies in the area of HIV/AIDS therapy reported from Georgia State University, Department of Biology
Published in AIDS Weekly and Law, March 8th, 2007
New investigation results, "Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114," are detailed in a study published in JMB Online. "TMC114 (darunavir) is a promising clinical inhibitor of HIV-1 protease (PR) for treatment of drug resistant HIV/AIDS. We report the ultra-high 0.84 A resolution crystal structure of the TMC114 complex with PR containing the drug-resistant mutation V32I (PR(V32I)), and the 1.22 A resolution structure of a complex with PR(M46L)," scientists in the United States report.
"These structures show TMC114 bound at two distinct sites, one in the active-site cavity and the second on...
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Source: AIDS Weekly and Law (2007-03-08)
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