HIV/AIDS

Study findings from La Sapienza University provide new insights into HIV/AIDS

Published in AIDS Weekly and Law, June 11th, 2009

"New potent indolylarylsulfone (IAS) HIV-I NNRTIs were obtained by coupling natural and unnatural amino acids to the 2-carboxamide and introducing different electron-withdrawing substituents at position 4 and 5 of the indole nucleus. The new IASs inhibited the HIV-1 replication in human T-lymphocyte (CEM) cells at low/subnanomolar concentration and were weakly cytostatic," researchers in Rome, Italy report.

"Against the mutant L100I, K103N, and Y181C RT HIV-1 strains in CEM cells, sulfones 3, 4, 19, 27, and 31 were comparable to EFV. The new IASs were inhibitors to Coxsackie B4 virus at low micromolar (2-9 mc M) concentrations. Superimposition of PLANTS docked...

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Source: AIDS Weekly and Law (2009-06-11)

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