Pathogenesis
Glycocorticoids May Inhibit T-Cell Apoptosis in HIV+
Published in AIDS Weekly, March 6th, 1995
During HIV-1 infection, CD4 T lymphocytes migrate to immune-reactive lymphoid organs where they are infected by the virus and/or killed by apoptosis or immunoregulatory stimuli - a potential mechanism underlying fatal CD4+ T-cell depletion observed in AIDS.
In vitro studies have shown that Cyclosporin A (CSA), a potent immunosuppressive drug with anti-apoptotic activity, is...
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Source: AIDS Weekly (1995-03-06)
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