Therapy

Fluconazole Reduces Fungal Infections in AIDS Patients

Published in AIDS Weekly, April 3rd, 1995

The antifungal agent fluconazole, given as prophylaxis, reduces the frequency of cryptococcosis, esophageal candidiasis, and superficial fungal infections in HIV-infected patients with low CD4 counts, according to a report from the NIAID AIDS Clinical Trials Group.

Invasive fungal infections, especially with Cryptococcus neoformans, occur in 5 to 10 percent of patients with AIDS. In addition, mucocutaneous candidiasis is almost ubiquitous in patients with advanced HIV disease, and recurrent infection causes considerable morbidity.

Fluconazole is an orally active triazole antifungal agent that is effective in preventing a relapse of...

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Source: AIDS Weekly (1995-04-03)

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