Prophylaxis

Three Anti-Pneumocystis Combined Agents Effective in ACTG Trial

Published in AIDS Weekly, April 10th, 1995

In severely immunodepressed AIDS patients trimethoprim-sulfamethoxazole and dapsone are more effective than aerosolized pentamidine in preventing Pneumocystis carinii pneumonia, according to a NIAID AIDS Clinical Trials Group (ACTG) study.

The ACTG report suggests that trimethoprim-sulfamethoxazole, high-dose dapsone, and aerosolized pentamidine are all effective in preventing PCP in AIDS patients, but it noted that in patients with CD4 counts under 100 lymphocytes per cubic millimeter the former two agents are superior to aerosolized pentamidine ("A Randomized Trial of Three Antipneumocystis Agents in Patients with Advanced HIV," The New England Journal of...

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Source: AIDS Weekly (1995-04-10)

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